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It is well known that TGF- prevents the sensitized T cells migration into the CNS, and protects against EAE and MS, while IL-12 may play a major role in EAE development through the induction of both Th1 and Th17 cells differentiation, and both may play a complementary role in the EAE disease pathogenesis (Jafarzadeh and Nemati, 2018)

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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction