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Several factors have been identified related to the pathogenesis of ALS: OS, mitochondrial dysfunction, neuroinflammation, excitotoxicity due to an increase in the neurotransmitter glutamate, defect in axonal transmission and in the metabolism of RNA, apoptosis, cytoskeletal abnormalities, disruption of membrane trafficking, endoplasmic reticulum stress, protein misfolding and aggregation (Papadimitriou et al., 2010

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Gua de Dosificacin Referencial (Clculo de Unidades) Para garantizar la integridad del compuesto liofilizado y la precisin de los datos obtenidos en la investigacin, se debe seguir un protocolo estricto de reconstitucin utilizando disolventes con conservantes qumicos