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For type 2 diabetes, screening should begin at diagnosis and annually thereafter (see screening algorithm in Figure 1)

2.4 Metabolic and mitochondrial dysfunction in diabetes An animal experiment using db/db mice, a model of type 2 diabetes, demonstrated that disturbances in circulatory metabolism and brain energy metabolism, particularly mitochondrial dysfunction, may contribute to cognitive impairment

Yet so many need treatment: The CDC reports that 29.5 million met AUD criteria in the past year

Not all medications work in the same way

Endocrinology 152 , 31033112 (2011)

Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis