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Among volume restoration techniques, lipofilling appears particularly promising owing to its dual volumizing and regenerative effects

The processes regulating skin pigmentation and hair pigmentation operate independently

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By inducing the receptor LGR4/5 to bind to Znrf3/Rnf43, R-Spondin, the negative feedback regulator of Wnt, removes the two E3 transmembrane ligases from the membrane, thus weakening the ubiquitination of Frizzled and significantly increasing the transmission of Wnt/-catenin signals

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