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However, we suggested that the lethality induced by LCS3 in VRK2-KO PC cells is primarily dependent on inhibiting the activity of GSR rather than TXNRD1, for the following reasons

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Increased production of this crucial hormone can reverse most of these effects

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The statistics cited (2-10x GH increase, 1.5-3x IGF-1 increase) are from published clinical studies

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This indicates that the combination therapy of oxaliplatin and NK cells holds promise for the treatment of platinum-resistant patients [134]

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Unlike SLC39A8 and SLC39A14 mutations, symptoms of SLC30A10 mutations can emerge in childhood or adulthood (Winslow et al., 2020

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