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Mice were administered a single topical drop (2.5 L) of NAC (18.35 mg/mL) or NACET (21.5 mg/mL) gel-forming drops, or gel-forming vehicle alone bilaterally daily starting from when their eyes opened (P13-15) through P65

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Gamma-glutamyltransferase 1 (GGT1), a key enzyme in glutathione homeostasis, is significantly down-regulated in chRCC compared with normal kidneys, while overexpression of GGT1 can inhibit the chRCC cells proliferation, and inhibit the cystine uptake and GSH levels (125)

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