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It also explains retatrutide's unique side effect: dysesthesia (abnormal skin sensations) is seen only in retatrutide users, not tirzepatide or semaglutide users, and is likely related to glucagon receptor activation or its downstream metabolic effects

Dehydration exacerbates constipation, headaches, and fatigue

Enhanced Insulin Sensitivity : GIP may improve insulin action in peripheral tissues

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8 Pentoxifylline Pentoxifylline is a non-specific phosphodiesterase inhibitor with anti-inflammatory and antifibrogenic properties

This includes reduced food preoccupation or food noise, reduced emotional eating, less external eating (i.e., eating that responds to external triggers, irrespective of satiety), and fewer binge eating episodes [56,149]