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It is a devastating disease with a lack of effective treatments and although the cause of the neuronal death in ALS is not known, it is suspected that oxidative damage plays a key role

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All of the above evidence suggest that in vivo, in vitro, and ex vivo studies along with these two computer-aided tools, PBPK and QSAR, could be used by researchers to more accurately assess human fetal exposure

41 Similarly, a study of 84 patients with acute pancreatitis demonstrated that those who received high dose intravenous vitamin C supplementation (10 grams/day) had a shorter hospital duration and lower mortality compared to those in the standard of care group

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Khan et al., 2019) (Table 1)