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J Biol Chem 246:402411 Shug AL, Shrago E, Bittar N, Folts JD, Koke JR (1975) Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

In the context of mucosal inflammation, the activation of NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS) by inflammatory cytokines leads to the production of superoxide and nitric oxide by intestinal epithelial cells (IECs), neutrophils, and macrophages ( Both ROS and RNS have been implicated in IBD pathogenesis, with a particular role in CD initiation and progression ( These ROS promote cell damage and harm tissue integrity by preventing the accumulation of antioxidant defenses in host cells

Funding This work was supported by R01 funding to R.V.S

PALL Life Sciences), added to Strep XT beads (400l [as 800l 50% slurry]), and incubated at 4C on a rotator for 2 h