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Among them, UQCRB is one of the subunits of the mitochondrial respiratory chain complex III, and mutations in UQCRB increase mtROS production and activate HIF-1 transactivation, promoting vascular neovascularization, a process that can be regulated by UQCRB inhibitors (209)

Glutaminase inhibition impairs cd8 T cell activation in stk11-/lkb1-deficient lung cancer

This was attributed to the higher intracellular glutathione content in the #14 mutant when cultured in the molasses/CSL-based medium (2.6%), 87% higher than in the YP-based medium

J Biol Chem 270(45):2699326999

Zhao Y-e, Peng Y, Wang X-l, et al

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