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The compound's ability to restore tissue homeostasis and reverse age-related functional decline in animal models provides direct evidence for the role of senescent cells in aging processes, while its applications in cancer research offer insights into senescence mechanisms in disease progression and administration resistance

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For example, glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 inhibitors used for T2D treatment originate from gut-derived signaling mechanisms 5

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Furthermore, we observed a lethal embryonic phenotype for the gbh-1 loss-of-function strains, which was rescued upon L-carnitine supplementation