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UV radiation, pollution, stress, and poor diet all generate free radicals that break down collagen and damage skin cells

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"A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy." Oncologist 18(11): 1190-1191

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For example, coding for the adjacent operative note is Q36.9 Cleft lip, unilateral and Q30.2 Fissured, notched and cleft nose