August 2024, Episode 195: In this episode, host Lindsay Weitzel, PhD, sits down with headache medicine specialist Fred Cohen, MD, and dives into a new topic: GLP-1 agonists
Established Findings Within Preclinical and Mechanistic Literature Published receptor pharmacology describes Retatrutide as a peptide with activity at GCGR, GIPR, and GLP-1R
Brush your teeth, floss, and rinse out your mouth with warm water
Some of the side effects we found, like nausea, are well known, and that shows that the method is picking up a real signal, says Sharath Chandra Guntuku, PhD, research associate professor in computer and information science at Penn Engineering and the studys senior author
At the molecular level, all three target receptors are Gs-coupled GPCRs that signal through cyclic AMP (cAMP) and protein kinase A (PKA), creating coordinated intracellular signaling that comprehensively shifts metabolism toward a catabolic state favoring fat oxidation and weight loss
This once-weekly injection represents the potential future of metabolic medicine