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The talk show host has been using Mounjaro, one of the GLP-1 drugs, since 2023

The therapeutic effects arise through three primary mechanisms: central appetite suppression via hypothalamic GLP-1R activation (reducing food intake by 20-35%), delayed gastric emptying through vagal pathways (enhancing satiety per meal), and glucose-dependent insulin secretion from pancreatic beta cells (improving glycemic control)

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Jason Itri guides treatment as part of a medically supervised, long-term plan