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Refrigerator Suitable for many lyophilized (freeze-dried) peptides and most reconstituted solutions Store in the main section of the refrigerator , not the door Protect from light exposure and moisture Freezer Use only if freezing is specifically permitted Store in airtight packaging or sealed containers Avoid repeated thawing and refreezing Keep vials sealed until ready for use Store in a cool and dry environment Protect from direct light, heat, and humidity Avoid locations with frequent temperature changes , such as vehicles or windowsills Use clean, dry laboratory tools and surfaces Avoid vigorous shaking

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

Omega-3 acts on a different measure

Distribution of cyclooxygenase-3 (COX-3) in rat nervous system

Free Radical Biology and Medicine 48, 13701381 (2010)

Los adultos pueden sintetizar por s mismos la concentracin de L-carnitina necesaria para mantener un metabolismo normal, pero la capacidad de sntesis de L-carnitina en los lactantes es ms dbil, representando solo del 12% al 15% de la de un adulto, especialmente en los bebs prematuros, lo que no puede satisfacer sus necesidades metablicas normales