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Studies conducted in mice and human foreskin fibroblasts have revealed that S-acetyl-glutathione molecules are taken up directly by cells with subsequent conversion to glutathione by cleavage of the acetyl bond within the cell

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Its levels also typically decline with age

Building on this initial imaging success, the National Institutes of Health (NIH) awarded a major grant for an ongoing randomized, double-blind, placebo-controlled clinical trial (NCT04542161) exploring much higher dosages of up to 3,600 mg/day of NAC

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