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Annu Rev Biochem 52:711760 Meuwly P, Thibault P, Rauser WE (1993) Gamma-Glutamylcysteinylglutamic acid a new homolog of glutathione in maize seedlings exposed to cadmium

Safety, Tolerability & Regulatory Status Safety Profile GHK-Cu demonstrates an excellent safety profile for cosmetic use: Naturally occurring in humans (plasma, saliva, urine) Non-sensitizing in standard patch testing at cosmetic concentrations Long history of topical application in anti-aging and wound care products Minimal reported adverse reactions at appropriate doses Usage Levels and Tolerability Regulatory Status EU : Permitted as a cosmetic ingredient with standard safety assessments US/Asia-Pacific : Allowed under respective cosmetic regulations Formulators must : Perform product-specific safety evaluations, including SDS review, toxicological profiles, and margin of safety calculations Addressing Copper Uglies Literature occasionally references theoretical over-stimulation of MMPs leading to collagen breakdown (sometimes called copper uglies)
All figures and pathways described are preclinical research observations