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The above-mentioned lactate is involved in Treg cell metabolism and promotes the nuclear translocation of nuclear factor of activated T-cells NFAT1 and enhances PD-1 expression, which suggests poor response to immunotherapy (168)

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Additionally, a rating of each study based upon the number of subjects studied, time interval of testing, dosing, technical parameters that were quantified, etc

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doi: 10.1016/j.bbrc.2009.03.151 278 SchmittC.TurnerD.BoeslM.AbeleM.FroschM.KurzaiO

[DOI] [PubMed] [Google Scholar] 22.Beer SM