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Four main MAPK cascades have been identified: ERK1/2 (extracellular signal-regulated kinases), c-Jun N-terminal kinases (JNK), p38 (p38 kinase), and the BMK1/ERK5 (big MAP kinase 1) (Schaeffer and Weber 1999)

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When looking at total social benefit, a broad definition that includes quality of life improvement measured by quality-adjusted life years (QALYs)[4], the figure reaches $6.7 trillion over 30 years[5]

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