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(2023) proposed twelve hallmarks of aging: genomic instability, telomere shortening, epigenetic alterations, impaired protein homeostasis, defective autophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and microbial imbalance

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Hydroxocobalamin regimen (UK example): 1 mg (1000 g) IM three times a week for 2 weeks (loading), then 1 mg every 3 months thereafter

(1983) 18(Suppl 1):3115

This phase is driven by rising interest in cellular health, detoxification, antioxidant replenishment, and endurance support