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To quantify the therapeutic effect of each drug on CNV, the length of the longest neovascularization growing vertically from the corneal rim in four quadrants was measured and calculated according to the CNV area formula: S = C/12 3.1416[r 2 (r l) 2 ], where C is the number of trans-circular clock points of the neovascular network, r is the radius of the rat cornea, l is the length of the neovascularization with small continuous curvature perpendicular to a line tangential to the cornea, and the average of the maximum vessel length in the four quadrants was calculated [37, 38]

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