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I see it appear suddenly and unpredictably in both new starters and long-term users, suggesting multiple overlapping mechanisms are usually at play rather than a single isolated cause

Patients with previous gastrointestinal medication use were 9% more likely to stop, suggesting vulnerability to common side effects like nausea, vomiting, and diarrhea

And glucagon receptor activation brings effects on fat burning and energy expenditure that the other two pathways dont cover

ALT / AST liver enzyme levels

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