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Hypertensive patients have been observed to produce high levels of hydrogen peroxide, superoxide anion, and NO in leukocytes [290,291,292], exhibit elevated lipid peroxidation in erythrocytes, and display elevated concentrations of 8-isoprostanes in plasma [293]

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Collectively, these findings illustrate an intricate network in which copper ions modulate cell fate by targeting multiple nodes of the ferroptotic pathway, presenting a promising avenue for therapeutic interventions

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