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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

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There are usually at least a few scattered pigmented macrophages (melanophages) present within the dermis

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The most common adverse reactions are related to gastrointestinal adjustments and administration site responses with subcutaneous injection protocols