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doi:10.1007/s00405-020-05925-9
A final consideration relates to the potential risk for GLP-1RA therapy to contribute to progression of pancreatic cystic lesions
Managing Side Effects in Combined Protocols Combining multiple peptides with Retatrutide creates potential for both additive benefits and compounded side effects
However, more is not automatically better
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Peripheral effects Via the AMY2 and AMY3 receptors Cagrilintide acts peripherally: Slowing of gastric emptying , stronger than with GLP-1 Suppression of postprandial glucagon , helps control postprandial glycemic spikes Modulation of bone remodeling (via AMY3), a neutral effect, but clinically monitored Synergy with GLP-1 (the mechanistic basis of CagriSema) The main innovation is the complementarity with the GLP-1 pathway : GLP-1 suppresses appetite via the arcuate nucleus of the hypothalamus (POMC neurons, AgRP/NPY inhibition) Amylin suppresses appetite via the area postrema (CGRP-like neurons) Two independent centers, two independent mechanisms
