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CT-388 activates both GLP-1 and GIP receptors with a unique signaling profile: Signal-biased dual agonism: Potent cAMP signaling at both GLP-1R and GIPR Minimal to no beta-arrestin recruitment at either receptor Reduced receptor internalization and desensitization Potentially prolonged pharmacological activity GLP-1 receptor activation: Appetite suppression via hypothalamic and brainstem receptors Glucose-dependent insulin secretion Glucagon suppression Gastric emptying delay GIP receptor activation: Additional insulin sensitization Enhanced lipid metabolism Complementary appetite regulation Potential adipose tissue remodeling benefits The biased signaling mechanism is the key differentiator

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Key differences between the two include their formulation and drug interactions

Steady State Steady state refers to the state of drug concentration in the body when the concentration of drug is no longer rising or falling

Purity & Third-Party Testing: Look for independent lab results, certifications (USP, NSF), CoA availability