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I was like, 'I look great, I'm so pretty,' but meanwhile I brushed it under the rug when I was experiencing something that was physically hurting," D'Agrella says

This resulted in the first generation of GLP-1 receptor agonists, including exenatide and lixisenatide

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219 It has been postulated that the ability of GLP-1 to enhance metabolism may decrease endoplasmic reticulum stress via increasing mitochondrial production of ATP and Ca 2+ , which could be utilised for assisting endoplasmic reticulum homeostasis

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