However, some users report new or worsening gut symptoms such as nausea, vomiting and slowed digestion after starting treatment
In the context of tirzepatide therapy, which strongly improves insulin sensitivity, this is unlikely to be a problem, but it is worth monitoring in individuals with diabetes or prediabetes
Semaglutide, a synthetic long-acting GLP-1 antagonist, stays in the body for longer than natural GLP-1
However, there is a possibility of receiving better results by taking them together
In clinical studies , nausea appears to be a dose-dependent side effect of semaglutide, which means that it is more common with higher doses
Side effects are most common when you first start using the medication or increase the dose, and higher doses of both drugs can lead to a higher risk of side effects