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While transdermal patch delivery systems are under investigation, all commercially available GLP-1 therapies require subcutaneous injection (semaglutide, liraglutide, dulaglutide, tirzepatide) or oral administration (Rybelsus)

Heres why muscle loss due to GLP-1 use should raise red flags: 1

These genetic abnormalities were identified in about 10% of infants following sulfonylurea exposure, 8% with GLP1R agonists, 7% with SGLT2 inhibitors, and 6% with DPP-4 inhibitors compared to about 8% with insulin

Obesity is expected to cost the UK economy billion per year when factoring in lost productivity, benefits, and wider societal impacts

Tham Kwang Wei is a senior consultant endocrinologist in Woodlands Health

MASLD Substudy Sanyal et al., Nature Medicine (2024) Sanyal and colleagues conducted a prespecified phase 2a substudy of the original phase 2 obesity trial, evaluating retatrutide in participants with metabolic dysfunction-associated steatotic liver disease (MASLD)