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Ozempic (semaglutide) produces approximately 15% average body weight loss, while Contrave produces 5-8%

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The combination makes sense for a specific subset: patients with significant weight to lose (50 lbs) who are physically active, willing to train consistently, and concerned about preserving muscle mass and metabolic rate during aggressive caloric restriction

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"The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness"