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Unlike oral supplements that require intrinsic factor for absorption in the gastrointestinal tract, vitamin B12 injections deliver the vitamin directly into bloodstream

10.1016/j.ejps.2018.12.011 122 LiuF.FengM.XingJ.ZhouX

Clinically, strategies aimed at modulating EAAC1-mediated cysteine transport and boosting endogenous GSH synthesis may hold promise for mitigating post-ischemic neurodegeneration and cognitive deficits associated with vascular dementia

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However, most researchers who tolerate this phase find that subsequent dose increases are easier, suggesting the body develops tolerance over time

doi: 10.1589/jpts.35.645 96