The consequence is that every dose of MT-II activates the entire suite of melanocortin effects simultaneously: melanogenesis through MC1R, appetite suppression through MC3R and MC4R in the arcuate nucleus, sexual arousal through MC4R in the paraventricular nucleus, and exocrine effects through MC5R
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If oral administration is a protocol requirement, MK-677 is pharmacologically viable
Uematsu A, Tan BZ, Ycu EA, Cuevas JS, Koivumaa J, Junyent F, Kremer EJ, Witten IB, Deisseroth K, Johansen JP (2017) Modular organization of the brainstem noradrenaline system coordinates opposing learning states
On paper, that sounds competitive
This rapid onset and short duration of action results in the ability of this class of drugs to predominantly reduce postprandial glucose levels (42)
