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ZIP14 KO mice had a higher glucose transport rate and higher glucose concentration in the liver than WT mice, due to a stronger expression of the glucose transporter GLUT2 at the plasma membrane

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References Ford AC, Harris LA, Lacy BE, Quigley EMM, Moayyedi P

S17834 can also activate adenosine monophosphate-activated protein kinase, so its therapeutic benefit may relate to this activity rather than NOX inhibition

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In PD animal models, AIF nuclear translocation in SN dopaminergic neurons coincides with motor deficits, while calpain inhibitors blocking AIF release significantly reduce neuronal death [71]