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However, chronic exposure to any exogenous agonist can lead to receptor internalization or downregulation

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You've ruled out other causes like product interactions or contamination

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Furthermore, the lack of cystathionine -synthase seemingly upregulates the expression of genes with regard to ER stress, hepatic lipid homeostasis, as well as genes linked to hepatic steatosis (57), whereas knockout of cystathionine -lyase results in decreased hepatic lipolysis (58)