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Finally, intact H3K27 trimethylation was seen in 31 of 265 (12%) melanomas, with 8 of 36 (22%) primary desmoplastic/fusiform melanomas (Figures 4f and g) and 23 of 229 (10%) melanoma metastases (Figure 5d)

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3) Advance next-generation ferroptosis modulators: Prioritize the development of kidney-targeted, stimuli-responsive delivery systems (e.g., ROS-sensitive LNPs and hypoxia-responsive polymers) to enhance tissue specificity and reduce systemic toxicity

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