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Conceptually, GEP is a prevalence-weighted expression metric: it becomes high when a cell class has both appreciable GLP1R transcript abundance and a meaningful proportion of cells that are GLP1R-positive

doi: 10.1016/j.jneuroim.2022.577995

Its GLP-1 activity is important, but it does not fully explain the compounds pharmacologic profile

For people struggling with weight management who've tried diet and exercise without lasting results, the rise of GLP-1 medications has created a new category of options

Patients should be advised to monitor for subtle changes such as jewellery or clothing feeling tighter, asymmetry between limbs, or skin texture changes

An initial model was built using ModelAngelo 53 and missing residues were added in Coot 54