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A patient can finish a course of GLP-1 treatment significantly lighter and simultaneously in a weaker metabolic position than when they started if muscle preservation was not part of the plan. This is the mechanism behind what clinicians commonly observe in weight cycling

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Sources: Kraemer, W

Mutations in the AQP2 gene are associated with a form of nephrogenic diabetes insipidus

Furthermore, fasting induces a metabolic shift from glucose to ketone utilization, providing neurons with a potent energy source that reduces mitochondrial stress and enhances bioenergetic stability [76]

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