Moreover, GPX4 in mitochondria exerts a more significant effect on cell resistance to ferroptosis than that exerted by GPX4 in the cytoplasm, and mitochondrial events seem to be final steps in the determination of whether cells undergo ferroptosis [287, 288]
From what we see, these restrictions could soon turn out to be a very costly strategy from care as well as cost perspective
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Thats exactly why so many lean individuals prefer microdosing ,it keeps muscle preservation front and center instead of forcing the body into an overly aggressive deficit