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The study authors suspect weight loss drives this effect, though GLP-1 agonists may also influence testosterone through their impact on inflammation and hormone signaling in the brain

Although we supplemented our study mice with a large dose of GSH (500 mg/kg), which was equivalent to that of 2500 mg/d for a 60 kg human [26], it had a hepatoprotective role in mice

We then concentrated on the mechanistic findings related to the acceleration of depression in the context of GD, as mounting evidence has indicated that GD promotes the development of depression through various mechanisms, including triggering autoimmune responses, inducing hormonal disorders, and influencing the thyroid-gut-microbiome-brain axis

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Cell Reports 44 (2025)