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For example, instead of 10mg once weekly, they inject 5mg twice weekly

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

Villous hypervascularization, characterized by an increased number of branches per capillary within terminal villi, is also observed in placentas affected by GDM [31]

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Each serving contains a 5,000 mcg mixture of methylcobalamin and adenosylcobalamin

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