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It also inhibits RSL3-induced ferroptosis in HT22 cells and reverses I/R injury through the GPX4/ACSL4/ACSL3 axis and PINK1-Parkin-mediated mitochondrial autophagy regulation (170, 171)
Bart J, Dijkers ECF, Wegman TD, et al
The discussed studies were obtained from databases (PubMed, SciFinder), using the keyword Pycnogenol and placebo or double-blind. 2 Randomized, double-blind placebo-controlled human clinical studies with Pycnogenol The RDP human clinical studies conducted with Pycnogenol are summarized in Table 1, including a brief description of the study details and main findings
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For mean separation, Tukeys HSD test was used at a confidence level of 95%
[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Jain S.K
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