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But first, verify that the plateau is real and not caused by other factors: water retention, increased muscle mass from exercise, dietary drift, or inconsistent injection timing

Bodyweight decreased dose dependently with retatrutide at doses of 4 mg, 8 mg, and 12 mg. Lancet, Endicronology This has led researchers to investigate individualized dosing strategies rather than a one-size-fits-all protocol

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Importantly, this follow-up occurred in the absence of active lifestyle intervention, which the authors themselves note may have contributed to weight regain