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Pharmaceutical-grade requires 99.5% or higher, a threshold that accounts for clinical dosing precision

It is important not to exceed the doses indicated by health professionals or on supplement labelling to avoid adverse side effects

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ChaC1 and ChaC2 use the -amine of L-glutamyl residues to cleave the amide bond by transamination, releasing it as a cyclic 5-oxo-l-proline and cysteine glycine dipeptide

Pregnancy and lactation A retrospective observational study reported that daily oral supplementation with 600 mg of lipoic acid (racemic mixture) during pregnancy and without interruption from a period spanning between week 10 and week 30 of gestation and until the end of week 37 was not associated with any adverse effect in mothers and their newborns (114)