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However, the primary concern is loss of potency rather than contamination

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1) XJB-5-131 (mitochondrial nitroxide) inhibits lipid peroxidation to prevent ferroptosis, reducing inflammatory infiltration and promoting tubular repair (113)

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Moreover, given that there are now millions of patient-years of clinical experience with DPP-4 inhibitors since they were given regulatory approval in 2006, their benign, placebo-like side effect profile (39) also suggests that the number of physiologically relevant substrates is likely to be limited