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Pediatric research

One possible explanation for the similar effects on weight loss observed with both GIPR agonism and antagonism might be that chronic pharmacological GIPR activation induces functional antagonism in a subset of neurons through receptor desensitization, as seen in adipocytes, isolated pancreatic islets and mouse neuroblastoma Neuro2a cells 36,37

While unsettling, the phenomenon is not surprising

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A study found that low-impact aerobic activity still offers substantial metabolic benefits