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Weight loss, which commonly occurs with tirzepatide therapy, can influence hormonal balance and thermoregulation, though evidence suggests that weight loss may actually improve vasomotor symptoms in some overweight postmenopausal women

Care 41 , S13S27 (2018)

The original patent documentation describes this mechanism in detail, noting that the peptide stimulates lipolysis and inhibits lipogenesis via beta-adrenergic signalling at concentrations far below those needed to activate growth-promoting pathways

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Long-term use might make it harder for the stomach to absorb B12 from food