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74 Chronic overnutrition, a sedentary lifestyle and IR in adipose tissue can directly lead to the production and accumulation of excess toxic lipid products (such as diacylglycerol, ceramides, and NEFAs), and the metabolites can aggravate the ectopic lipid deposition through some signaling pathways (such as mTOR and notch)
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McCurley, A
The MAD theory integrates the Tau and Amyloid theories with the pathogen-based theories such as the endotoxin theory of AD (Brown and Heneka, 2024) and viral AD (Itzhaki, 2021
Dose escalation was planned for part A (SAD
Doxycycline belongs to the tetracycline class of antibiotics
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