Potential breaking of weight-loss plateaus, especially when standard diet/exercise alone have slowed
Blom HJ, Engelen DPE, Boers GHJ, Stadhouders AM, Sengers RCA, De Abreu R, TePoele-Pothoff MTWB, and Trijbels JMF (1992)
SIRT1 is also known as the longevity gene because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer
EP thanks the NRF of South Africa (grant number 142142) and SA MRC (self-initiated research (SIR) grant)
Potential Benefits & Side Effects Evidence tier: approved drug with positive randomized phase 3 data genuinely strong, and genuinely narrow
DDX3X modulates perinuclear virion accumulation Given the repositioning of DDX3X, we wondered if this was functionally relevant for the virus