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However, ROS production is significantly increased in cancer cells because of mitochondrial dysfunction, altered metabolism, and frequent genetic mutations, resulting in an accumulation of large amounts of oxidized protein, DNA, and lipids (Demple and Harrison, 1994)
Miniaturizing immunoassays to the nanoliter scale reduces reagent and sample consumption, making it possible, for example, to perform one mouse, one PK studies that minimize animal use and biological variation in preclinical studies and maximize data quality
Perivascular clustering of NG2-glia, particularly in active multiple sclerosis lesions, impairs their ability to appropriately separate from vessels following perivascular migration
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