It mimics a single gut hormone called glucagon-like peptide-1, which slows gastric emptying, reduces appetite, and improves insulin sensitivity
That can lead to changes in shoe size
[55] In adipose tissue, it significantly decreases the infiltration of macrophages and suppresses the expression of neutrophil inflammatory factors like S100A8, S100A9, and CXCL2
A slower metabolism can lead to a plateau in weight loss because your body is using fewer calories to maintain its new body mass
For people requiring more intensive glucose control , triple therapy (metformin plus two other agents from different classes, but not combining DPP-4 inhibitors with GLP-1 receptor agonists) or insulin therapy may be necessary
Tirzepatide, the heart of Mounjaro and Zepbound, functions as a dual-action agent affecting GLP-1 and GIP receptors